Пермяков Евгений Анатольевич

Ученое звание и ученая степень:
доктор биологических наук, профессор

Должность:
Декан факультета биомедицинской инженерии

Преподаваемая дисциплина:
Основы физико-химической биологии

Основные публикации за последние 5 лет:
1.Nemashkalova EL, Permyakov EA, Permyakov SE, Litus EA. Modulation of linoleic acid-binding properties of human serum albumin by divalent metal cations. Biometals. 2017;30(3):341-53. doi: 10.1007/s10534-017-0010-5. PubMed PMID: WOS:000401061400003.
2. Lomonosova AV, Ulitin AB, Kazakov AS, Mirzabekov TA, Permyakov EA, Permyakov SE. Derivative of Extremophilic 50S Ribosomal Protein L35Ae as an Alternative Protein Scaffold. PLoS One. 2017;12(1). doi: e0170349 10.1371/journal.pone.0170349. PubMed PMID: WOS:000392381100057.
3. Kazakov AS, Sokolov AS, Vologzhannikova AA, Permyakova ME, Khorn PA, Ismailov RG, et al. Interleukin-11 binds specific EF-hand proteins via their conserved structural motifs. Journal of Biomolecular Structure & Dynamics. 2017;35(1):78-91. doi: 10.1080/07391102.2015.1132392. PubMed PMID: WOS:000392857000007.
4.Denesyuk AI, Permyakov SE, Johnson MS, Permyakov EA, Denessiouk K. Novel calcium recognition constructions in proteins: Calcium blade and EF-hand zone. Biochemical and Biophysical Research Communications. 2017;483(3):958-63. doi: 10.1016/j.bbrc.2017.01.040. PubMed PMID: WOS:000393726400009.
5.Zernii EY, Baksheeva VE, Iomdina EN, Averina OA, Permyakov SE, Philippov PP, et al. Rabbit Models of Ocular Diseases: New Relevance for Classical Approaches. Cns & Neurological Disorders-Drug Targets. 2016;15(3):267-91. doi: 10.2174/1871527315666151110124957. PubMed PMID: WOS:000373801100003.
6.Uversky VN, Permyakov SE, Breydo L, Redwan EM, Almehdar HA, Permyakov EA. Disorder in Milk Proteins: alpha-Lactalbumin. Part B. A Multifunctional Whey Protein Acting as an Oligomeric Molten Globular «Oil Container» in the Anti-Tumorigenic Drugs, Liprotides. Current Protein & Peptide Science. 2016;17(6):612-28. doi: 10.2174/1389203717666151203003151. PubMed PMID: WOS:000380779600010.
7.Sokolov AS, Kazakov AS, Solovyev VV, Ismailov RG, Uversky VN, Lapteva YS, et al. Expression, Purification, and Characterization of Interleukin-11 Orthologues. Molecules. 2016;21(12). doi: 1632 10.3390/molecules21121632. PubMed PMID: WOS:000392140100026.
8.Permyakov EA, Uversky VN, Permyakov SE. Interleukin-11: A Multifunctional Cytokine with Intrinsically Disordered Regions. Cell Biochemistry and Biophysics. 2016;74(3):285-96. doi: 10.1007/s12013-016-0752-7. PubMed PMID: WOS:000382847900001.
9.Permyakov EA, Permyakov SE, Breydo L, Redwan EM, Almehdar HA, Uversky VN. Disorder in Milk Proteins: alpha-Lactalbumin. Part A. Structural Properties and Conformational Behavior. Current Protein & Peptide Science. 2016;17(4):352-67. doi: 10.2174/138920371704160405001222. PubMed PMID: WOS:000373456800005.
10.Permyakov EA, Permyakov SE, Breydo L, Redwan EM, Almehdar HA, Uversky VN. Disorder in Milk Proteins: alpha-Lactalbumin. Part C. Peculiarities of Metal Binding. Current Protein & Peptide Science. 2016;17(8):735-45. doi: 10.2174/1389203717666160530151534. PubMed PMID: WOS:000388576500002.
11.Zernii EY, Nazipova AA, Gancharova OS, Kazakov AS, Serebryakova MV, Zinchenko DV, et al. Light-induced disulfide dimerization of recoverin under ex vivo and in vivo conditions. Free Radical Biology and Medicine. 2015;83:283-95. doi: 10.1016/j.freeradbiomed.2015.03.001. PubMed PMID: WOS:000355577600028.
12.Zernii EY, Grigoriev, II, Nazipova AA, Scholten A, Kolpakova TV, Zinchenko DV, et al. Regulatory function of the C-terminal segment of guanylate cyclase-activating protein 2. Biochimica Et Biophysica Acta-Proteins and Proteomics. 2015;1854(10):1325-37. doi: 10.1016/j.bbapap.2015.05.005. PubMed PMID: WOS:000362307500010.
13.Stovbun SV, Skoblin AA, Bulygin FV, Minaev VL, Kompanets VO, Laptev VB, et al. Structural transitions in chiral solutions and a microscopic model of a chiral string. Russian Journal of Physical Chemistry B. 2015;9(2):193-200. doi: 10.1134/s1990793115020116. PubMed PMID: WOS:000354390900005.
14.Permyakov SE, Permyakov EA, Uversky VN. Intrinsically disordered caldesmon binds calmodulin via the «buttons on a string» mechanism. PeerJ. 2015;3. doi: e1265 10.7717/peerj.1265. PubMed PMID: WOS:000364325500008.
15.Lomonosova AV, Ovchinnikova EV, Kazakov AS, Denesyuk AI, Sofin AD, Mikhailov RV, et al. Extremophilic 50S Ribosomal RNA-Binding Protein L35Ae as a Basis for Engineering of an Alternative Protein Scaffold. PLoS One. 2015;10(8). doi: e0134906 10.1371/journal.pone.0134906. PubMed PMID: WOS:000359062300075.
16.Kazakov AS, Sokolov AS, Rastrygina VA, Solovyev VV, Ismailov RG, Mikhailov RV, et al. High-affinity interaction between interleukin-11 and S100P protein. Biochemical and Biophysical Research Communications. 2015;468(4):733-8. doi: 10.1016/j.bbrc.2015.11.024. PubMed PMID: WOS:000367868500035.
17.Demidenko AV, Kudryakova NV, Karavaiko NN, Kazakov AS, Cherepneva GN, Shevchenko GV, et al. The ABA-binding protein AA1 of Lupinus luteus is involved in ABA-mediated responses. Russian Journal of Plant Physiology. 2015;62(2):161-70. doi: 10.1134/s1021443715020053. PubMed PMID: WOS:000349375700003.
18.Breydo L, Sales AE, Ferreira L, Fedotoff O, Shevelyova MP, Permyakov SE, et al. Effects of osmolytes on protein-solvent interactions in crowded environment: Analyzing the effect of TMAO on proteins in crowded solutions. Archives of Biochemistry and Biophysics. 2015;570:66-74. doi: 10.1016/j.abb.2015.02.021. PubMed PMID: WOS:000352332400009.
19.Baksheeva VE, Nazipova AA, Zinchenko DV, Serebryakova MV, Senin, II, Permyakov SE, et al. Ca2+-Myristoyl Switch in Neuronal Calcium Sensor-1: A Role of C-Terminal Segment. Cns & Neurological Disorders-Drug Targets. 2015;14(4):437-51. PubMed PMID: WOS:000354179100004.
20.Permyakov SE, Kazakov AS, Avkhacheva NV, Permyakov EA. Parvalbumin as a metal-dependent antioxidant. Cell Calcium. 2014;55(5):261-8. doi: 10.1016/j.ceca.2014.03.001. PubMed PMID: WOS:000336354700004.
21.Kaspersen JD, Pedersen JN, Hansted JG, Nielsen SB, Sakthivel S, Wilhelm K, et al. Generic Structures of Cytotoxic Liprotides: Nano-Sized Complexes with Oleic Acid Cores and Shells of Disordered Proteins. Chembiochem. 2014;15(18):2693-702. doi: 10.1002/cbic.201402407. PubMed PMID: WOS:000346023500010.
22.Nemashkalova EL, Kazakov AS, Khasanova LM, Permyakov EA, Permyakov SE. Structural Characterization of More Potent Alternatives to HAMLET, a Tumoricidal Complex of alpha-Lactalbumin and Oleic Acid. Biochemistry. 2013;52(36):6286-99. doi: 10.1021/bi400643s. PubMed PMID: WOS:000330099900016.
23.Lapteva YS, Uversky VN, Permyakov SE. Sequence microheterogeneity of parvalbumin, the major fish allergen. Biochimica Et Biophysica Acta-Proteins and Proteomics. 2013;1834(8):1607-14. doi: 10.1016/j.bbapap.2013.04.025. PubMed PMID: WOS:000321802200018.

Патенты:
WO2015174978 A1: “Antibodies against human receptor integrin alpha-4” by Ilya ALEXANDROV, Khikmet SADYKOV, Roman MIKHAILOV, Dina ABRAMOVICH, Sergei PERMYAKOV, Tajib Mirzabekov, Alexey REPIK, Vasily IGNATIEV, Mikhail Samsonov, Yan Lavrovsky

Образование:
Московский физико-технический институт, 1998, специальность «Прикладные математика и физика», специализация «Физико-химическая биология и биофизика»

Стаж работы преподавателем: 10 лет

Победы в грантах и научных проектах:
Soros student (International Soros Science Education Program), 1996-1998
Scholarship for research work at the Umeå University, Sweden (Visby Programme of the Swedish Institute), 2003
Grant CRDF RUB2-010001-PU-05, 2005
Grant of the Russian Federal Agency for Science and Innovations 02.442.11.7542, 2006
Grant from the «Russian Science Support Foundation», 2006
Grant from the President of Russia NMK-4581.2007.4, 2007-2008
Grant from the Russian Foundation for Basic Research RFBR 11-04-00860a, 2011-2012
Grant from the Program of the Russian Academy of Sciences «Fundamental Sciences to Medicine», 2012
Grant from the Program of the Russian Academy of Sciences «Fundamental Sciences to Medicine», 2013
Grant from the Program of the Russian Academy of Sciences «Fundamental Sciences to Medicine», 2014
Grant from the Russian Foundation for Basic Research and the Ministry of Investments and Innovations of the Moscow region №14-44-03604, 2014-2016

Индекс Хирша: 15 (WOS) 19

Участие в редколлегии журналов: редактор Current Protein & Peptide Science (Bentham Science)

Краткая трудовая биография:
Область научных интересов: структурно-функциональные свойства металлсвязывающих и внутренне неупорядоченных белков; белок-лигандные и белок-белковые взаимодействия; фоторецепция; фазовые диаграммы лиганд-связывающих белков; альтернативные каркасные белки; окислительный стресс.
Выполнение проектов по разносторонней физико-химической характеризации терапевтических белков для ряда фармацевтических компаний РФ: АО «Р-Фарм», ЗАО «БИОКАД», ООО «МБЦ Генериум», ООО «ФАРМАПАРК», ООО «Антерикс», ООО «Миранта Диагностикс».
Закончил МФТИ в 1998 г (специализация «Физико-химическая биология и биофизика»). С 1998 года – научный сотрудник ИБП РАН. С 2008 года – ведущий научный сотрудник ИБП РАН. Руководитель группы Исследования белков ИБП РАН с 2007 года. С 2007 года чтение лекций в ПущГЕНИ, курс «Основы физико-химической биологии». С 2016 года – и.о. зав. лаборатории Новых методов в биологии ИБП РАН.

Опыт работы за рубежом:
— Ohio State University, Department of Chemistry (1998 – 2000 гг);
— University of California, Santa Cruz, Department of Chemistry and Biochemistry (1999 г);
— University of Denver, Chemistry Department (2002, 2003 гг);
— Department of Biochemistry, Umeå University, Sweden (2003 г).

Регистрация на экскурсию по факультетам ПущГЕНИ - филиала РОСБИОТЕХ

Пермяков Евгений Анатольевич