Дьяченко Игорь Александрович

Ученое звание и ученая степень:
кандидат биологических наук

Преподаваемые дисциплины:

• Методы проведения испытаний по медицинской и экологической безопасности
• Принципы надлежащей лабораторной практики (GLP стандарт)
• Этапы жизненного цикла лекарственных средств согласно GMP, GSP, GDP,GPP

Публикации за последние 5 лет:

• Sintsova OV, Palikov VA, Palikova YA, Klimovich AA, Gladkikh IN, Andreev YA, Monastyrnaya MM, Kozlovskaya EP, Dyachenko IA, Kozlov SA, Leychenko EV (2020). Peptide Blocker of Ion Channel TRPV1 Exhibits a Long Analgesic Effect in the Heat Stimulation Model.Dokl Biochem Biophys493 (1), 215–217
• Babenko VV, Ziganshin RH, Weise C, Dyachenko I, Shaykhutdinova E, Murashev AN, Zhmak M, Starkov V, Hoang AN, Tsetlin V, Utkin Y (2020). Novel Bradykinin-Potentiating Peptides and Three-Finger Toxins from Viper Venom: Combined NGS Venom Gland Transcriptomics and Quantitative Venom Proteomics of the Azemiops feae Viper. Biomedicines 8 (8),
• Belozerova OA, Osmakov DI, Vladimirov A, Koshelev SG, Chugunov AO, Andreev YA, Palikov VA, Palikova YA, Shaykhutdinova ER, Gvozd AN, Dyachenko IA, Efremov RG, Kublitski VS, Kozlov SA (2020). Sevanol and Its Analogues: Chemical Synthesis, Biological Effects and Molecular Docking.Pharmaceuticals (Basel)13 (8), 1–21
• Palikov VA, Palikova YA, Borozdina NA, Nesmeyanova EN, Rudenko PA, Kazakov VA, Kalabina EA, Bukatin MV, Zharmukhamedova TY, Khokhlova ON, Dyachenko IA (2020). A novel view of the problem of Osteoarthritis in experimental rat model. Res. Pharm.6 (2), 19–25
• Palikov VA, Palikova YA, Dyachenko IA (2020). Study of protective properties of butyrylcholinesterase in acute anticholinesterase poisoning on BChE-KO and BALB/c mice. Res. Pharm.6 (1), 41–45
• Akimov MG, Kudryavtsev DS, Kryukova EV, Fomina-Ageeva EV, Zakharov SS, Gretskaya NM, Zinchenko GN, Serkov IV, Makhaeva GF, Boltneva NP, Kovaleva NV, Serebryakova OG, Lushchekina SV, Palikov VA, Palikova Y, Dyachenko IA, Kasheverov IE, Tsetlin VI, Bezuglov VV (2020). Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System. Biomolecules 10 (2),
• Palikova YA, Palikov VA, Dyachenko IA (2019). Maximum tolerant dose and analgesic activity of PT1 peptide. Res. Pharm.5 (3), 37–42
• Osmakov DI, Koshelev SG, Palikov VA, Palikova YA, Shaykhutdinova ER, Dyachenko IA, Andreev YA, Kozlov SA (2019). Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties. Toxins (Basel) 11 (9),
• Dyachenko IA, Murashev AN (2019). Features of the pharmacological activity of polypeptide modulators on acid-sensitive ion channels in the experiment. Res. Pharm.55 (2), 65–70
• Rudenko PA, Rudenko VB, Rudenko AA, Khokhlova ON, Kazakov VA, Rzhevskiy DI, Dyachenko IA (2019). The effectiveness of probiotic-sorption compounds in the complex treatment of sepsis in cats.Res J Pharm Biol Chem Sci10 (1), 1734–1739
• Rudenko PA, Rudenko VB, Rudenko AA, Khokhlova ON, Kazakov VA, Rzhevskiy DI, Dyachenko IA (2019). The effectiveness of probiotic-sorption compounds in the complex treatment of sepsis in cats.Dusunen Adam10 (1), 1734–1739
• Andreev YA, Osmakov DI, Koshelev SG, Maleeva EE, Logashina YA, Palikov VA, Palikova YA, Dyachenko IA, Kozlov SA (2018). Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight Compounds. Mar Drugs 16 (12),
• Palikov VA, Terekhov SS, Palikova YA, Khokhlova ON, Kazakov VA, Dyachenko IA, Panteleev SV, Mokrushina YA, Knorre VD, Shamborant OG, Smirnov IV, Gabibov AG (2018). Mouse Model for Assessing the Subchronic Toxicity of Organophosphate Pesticides.Acta Naturae10 (4), 125–128
• Palikova YA, Skobtsova LA, Zharmukhamedova TY, Palikov VA, Rudenko VB, Khokhlova ON, Lobanov AV, Rzhevskii DI, Slashcheva GA, Dyachenko EV, Belous GI, Andreev YA, Logashina YA, Kozlov SA, Yavorskii AN, Elyakova EG, Dyachenko IA (2018). Influence of New Promising Analgesic Compounds on Locomotor Activity of Mice.PHARM CHEM J52 (8), 700–703
• Palikova YA, Skobtsova LA, Palikov VA, Belous GI, Khokhlova ON, Lobanov AV, Slashcheva GA, Rzhevskii DI, Rudenko VB, Kalabina EA, Osipova GA, Andreev YA, Logashina YA, Kozlov SA, Yavorskii AN, Elyakova EG, Dyachenko IA (2018). Effects of Novel Potential Analgesic Compounds on the Cardiovascular and Respiratory Systems.PHARM CHEM J52 (7), 593–595
• Dyachenko IA, Belous GI, Skobtsova LA, Zharmukhamedova TY, Palikov VA, Palikova YA, Dyachenko EV, Kalabina EA, Rudenko VB, Andreev YA, Logashina YA, Kozlov SA, Yavorskii AN, Murashev AN (2018). Analgesic Activity of a Polypeptide Modulator of TRPV1 Receptors.PHARM CHEM J52 (3), 213–215
• Esipov RS, Makarov DA, Stepanenko VN, Kostromina MA, Muravyova TI, Andreev YA, Dyachenko IA, Kozlov SA, Grishin EV (2018). Pilot production of the recombinant peptide toxin of Heteractis crispa as a potential analgesic by intein-mediated technology.Protein Expr Purif145, 71–76
• Palikova YA, Zharmukhamedova TY, Palikov VA, Khokhlova ON, Osipova GA, Andreev YA, Logashina YA, Kozlov SA, Yavorskii AN, Murashev AN, DYachenko IA (2018). Analgesic activity of a natural peptide capable of specific binding to purinergic (P2x3) receptors.Eksp i Klin Farm81 (3), 12–14
• Dyachenko IA, Palikov VA, Palikova YA, Belous GI, Murashev AN, Andreev YA, Logashina YA, Maleeva EE, Grishin EV, Kozlov SA (2017). Single mutation in peptide inhibitor of TRPV1 receptor changes its effect from hypothermic to hyperthermic level in animals. J. Bioorganic Chem.43 (5), 509–516
• Terekhov SS, Palikov VA, Palikova YA, Dyachenko IA, Shamborant OG, Smirnov IV, Masson P, Gabibov AG (2017). Application of Tetrameric Recombinant Human Butyrylcholinesterase as a Biopharmaceutical for Amelioration of Symptoms of Acute Organophosphate Poisoning.Bull Exp Biol Med163 (4), 430–435
• Mokrushina YA, Stepanova AV, Palikov VA, Stepanov AV, Belous GI, Dyachenko IA, Knorre VD, Smirnov IV, Gabibov AG (2017). A Study of the Protective Properties of an Antibody-Based Antidote Metabolizing Organophosphorus Pesticide Paraoxon.Bull Exp Biol Med163 (2), 218–221
• Logashina YA, Solstad RG, Mineev KS, Korolkova YV, Mosharova IV, Dyachenko IA, Palikov VA, Palikova YA, Murashev AN, Arseniev AS, Kozlov SA, Stensvåg K, Haug T, Andreev YA (2017). New disulfide-stabilized fold provides sea anemone peptide to exhibit both antimicrobial and TRPA1 potentiating properties. Toxins (Basel) 9 (5),
• Logashina YA, Mosharova IV, Korolkova YV, Shelukhina IV, Dyachenko IA, Palikov VA, Palikova YA, Murashev AN, Kozlov SA, Stensvåg K, Andreev YA (2017). Peptide from sea anemone metridium senile affects transient receptor potential ankyrin-repeat 1 (TRPA1) function and produces analgesic effect.J Biol Chem292 (7), 2992–3004
• Rzhevskiy DI, Kravchenko IN, Sadovnikova ES, Rasskazova EA, Novikova NN, Ponomareva TI, Bondarenko DA, Semushina SG, Dyachenko IA, Shayhutdinova ER, Pakhomova IA, Kalabina EA, Zinchenko DV, Bogachuk AP, Azev VN, Lipkin VM, Murashev AN (2017). Preclinical safety studies of the drug with nootropic activity, based on the amide form of the leukocytes differentiation factor fragment.Russian Journal of Biopharmaceuticals9 (4), 50–56
• Skobtsova LA, Dyachenko IA, Andreev YA, Logashina YA, Murashev AN, Grishin EV (2016). Effect of polypeptides from sea anemone Heteractis crispa on the rodent blood pressure, heart rate, and hemostasis.Dokl Biol Sci470 (1), 228–230
• Stepanov A, Belyy A, Kasheverov I, Rybinets A, Dronina M, Dyachenko I, Murashev A, Knorre V, Sakharov D, Ponomarenko N, Tsetlin V, Tonevitsky A, Deyev S, Belogurov A, Gabibov A (2016). Development of a recombinant immunotoxin for the immunotherapy of autoreactive lymphocytes expressing MOG-specific BCRs.Biotechnol Lett38 (7), 1173–1180
• Osmakov DI, Koshelev SG, Andreev YA, Dyachenko IA, Bondarenko DA, Murashev AN, Grishin EV, Kozlov SA (2016). Conversed mutagenesis of an inactive peptide to ASIC3 inhibitor for active sites determination.Toxicon116, 11–16
• Dubinin MV, Astashev ME, Penkov NV, Gudkov SV, Dyachenko IA, Samartsev VN, Belosludtsev KN(2016).Effects of Phospholipase A2Inhibitors on Bilayer Lipid Membranes.J Membr Biol249 (3), 339–347
• Terekhov S, Smirnov I, Bobik T, Shamborant O, Zenkova M, Chernolovskaya E, Gladkikh D, Murashev A, Dyachenko I, Palikov V, Palikova Y, Knorre V, Belogurov A, Ponomarenko N, Blackburn GM, Masson P, Gabibov A (2015). A novel expression cassette delivers efficient production of exclusively tetrameric human butyrylcholinesterase with improved pharmacokinetics for protection against organophosphate poisoning.Biochimie118, 51–59
• Dyachenko IA, Andreev YA, Logashina YA, Murashev AN, Grishin EV (2015). Biological activity of a polypeptide modulator of TRPV1 receptor.Dokl Biol Sci465 (1), 279–281
• Terekhov SS, Smirnov IV, Shamborant OG, Bobik TV, Ilyushin DG, Murashev AN, Dyachenko IA, Palikov VA, Knorre VD, Belogurov AA, Ponomarenko NA, Kuzina ES, Genkin DD, Masson P, Gabibov AG (2015). Chemical polysialylation and in vivo tetramerization improve pharmacokinetic characteristics of recombinant human butyrylcholinesterase-based bioscavengers.Acta Naturae7 (4), 136–141
• Batchu SN, Smolock EM, Dyachenko IA, Murashev AN, Korshunov VA (2015). Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice. J Am Heart Assoc 4 (5),
• Bondarenko DA, Richter VA, Kuligina EV, Koval OA, Fomin AS, Skoblov YS, Dyachenko IA, Kravchenko IN, Sadovnikova EA, Semushina SG, Novikova NI, Turobov VI, Murashev AN (2015). Toxicity studies and pharmacokinetics of lactaptin. Russian Journal of Biopharmaceuticals 7 (2), 40–47